Mycophenolate mofetil

Name: Mycophenolate mofetil
Brand: Tocris Bioscience
SKU: 4102

Tocris Bioscience, part of Bio-Techne | Catalog # 4102

Citations (3)

COA / SDS

Inosine monophosphate dehydrogenase (IMPDH) inhibitor

Key Product Details

Description:	Inosine monophosphate dehydrogenase (IMPDH) inhibitor
Chemical Name:	6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid 2-(4-morpholinyl)ethyl ester
Purity:	≥98% (HPLC)
Molecular Weight:	433.49

View Full Technical Details for Mycophenolate mofetil

Technical Data
Citations

Biological Activity for Mycophenolate mofetil

Mycophenolate mofetil is an immunosuppressant prodrug of mycophenolic acid (MPA) (Cat. No. 1505). Hydrolyzed by esterases to release MPA, a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). Used to prevent organ rejection after transplantation. Displays inhibitory activity of lymphocyte functions. Inhibits type 1 collagen expression, enhances MMP-1 expression, and reduces α-smooth muscle actin gene expression.

Compound Libraries for Mycophenolate mofetil

Mycophenolate mofetil is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Mycophenolate mofetil

M. Wt	433.49
Formula	C₂₃H₃₁NO₇
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	128794-94-5
PubChem ID	5281078
InChi Key	RTGDFNSFWBGLEC-SYZQJQIISA-N
Smiles	O=C(OC2)C1=C2C(C)=C(OC)C(C/C=C(C)/CCC(OCCN3CCOCC3)=O)=C1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Mycophenolate mofetil

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	43.35	100
	ethanol	4.33	10

Preparing Stock Solutions for Mycophenolate mofetil

The following data is based on the product molecular weight 433.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.31 mL	11.53 mL	23.07 mL
5 mM	0.46 mL	2.31 mL	4.61 mL
10 mM	0.23 mL	1.15 mL	2.31 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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References for Mycophenolate mofetil

References are publications that support the biological activity of the product.

Roos In vitro evidence for a direct antifibrotic role of the immunosuppressive drug mycophen. mofetil. J.Pharm.Exp.Ther.
Allison and Eugui Purine metabolism and immunosuppressive effects of mycophen. mofetil (MMF). Clin.Transplant. 1996 PMID: 8680053