MTK 458
Tocris Bioscience, part of Bio-Techne | Catalog # 7980
PINK1 activator
Product Description
MTK 458 is a brain penetrant PTEN-induced kinase 1 (PINK1) activator. It binds to and stabilizes the active form of PINK1, increasing its activity and activating mitophagy downstream. It mediates clearance of pathogenic α-synuclein and normalizes pS65-Ubiquitin (pUb) in in vivo Parkinson's models. MTK458 is orally bioavailable.Licensing Information
Sold with kind permission of MitokininProduct Specifications
Molecular Weight
332.33
Formula
C17H15F3N4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[(1R)-1,2,3,4-Tetrahydro-1-naphthalenyl]-6-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS Number
2499962-58-0
PubChem ID
155187445
InChI Key
JOIONRWKOGDQOG-CYBMUJFWSA-N
SMILES
FC(F)(F)C1=CC(C(N1)=NC=N2)=C2N[C@H]3C4=CC=CC=C4CCC3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 16.62 | 50 | |
| Ethanol | 6.65 | 20 |
Preparing Stock Solutions
for MTK 458
The following data is based on the product molecular weight 332.33
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 6.02 mL | 30.09 mL | 60.18 mL |
| 2.5 mM | 1.20 mL | 6.02 mL | 12.04 mL |
| 5 mM | 0.60 mL | 3.01 mL | 6.02 mL |
| 25 mM | 0.12 mL | 0.60 mL | 1.20 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Chin Pharmacological PINK1 activation ameliorates pathology in Parkinson's disease models. bioRxiv 2023 PMID: 36824886
Product Specific Notices for MTK 458
For research use only
Loading...
Loading...