MSC 4381

Name: MSC 4381
Brand: Tocris Bioscience
SKU: 8008

Tocris Bioscience, part of Bio-Techne | Catalog # 8008

COA / SDS

Potent and selective monocarboxylate transporter 4 (MCT4) inhibitor

Key Product Details

Description:	Potent and selective monocarboxylate transporter 4 (MCT4) inhibitor
Chemical Name:	5-[2-[5-Chloro-2-[[(5-ethoxy-8-quinolinyl)sulfonyl]amino]phenyl]ethynyl]-4-methoxy-2-pyridinecarboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	537.97

View Full Technical Details for MSC 4381

Technical Data
Citations

Biological Activity for MSC 4381

MSC 4381 is a potent and selective monocarboxylate transporter 4 (MCT4) inhibitor (IC₅₀ = 77 nM; K_i = 11 nM). Inhibits lactate efflux in MDA-MB-231 cells (IC₅₀ = 1 nM) and reduces viability of cells expressing high levels of MCT4.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MSC 4381 probe summary on the SGC website.

Technical Data for MSC 4381

M. Wt	537.97
Formula	C₂₆H₂₀ClN₃O₆S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2445185-57-7
PubChem ID	150189198
InChi Key	FNBUZGRPJLEIMO-UHFFFAOYSA-N
Smiles	O=C(C1=NC=C(C(OC)=C1)C#CC2=CC(Cl)=CC=C2NS(=O)(C3=CC=C(C4=CC=CN=C43)OCC)=O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MSC 4381

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	26.9	50

Preparing Stock Solutions for MSC 4381

The following data is based on the product molecular weight 537.97.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.72 mL	18.59 mL	37.18 mL
2.5 mM	0.74 mL	3.72 mL	7.44 mL
5 mM	0.37 mL	1.86 mL	3.72 mL
25 mM	0.07 mL	0.37 mL	0.74 mL

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References for MSC 4381

References are publications that support the biological activity of the product.

Heinrich Discovery of 5-{2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic acid, a highly selective in vivo eseable chemical probe to dissect MCT4 biology. J.Med.Chem. 2021 PMID: 34382802