MS 41 New
Tocris Bioscience, part of Bio-Techne | Catalog # 8919
Potent and selective ENL Degrader (PROTAC®)
Key Product Details
Description
Potent and selective ENL Degrader (PROTAC®)
Product Description
MS 41 is a potent and selective Eleven-Nineteen Leukemia (ENL) Degrader (PROTAC®) (DC50 = 2.84 nM, 3.03 nM, 3.50 nM and 26.58 nM in SEMK2, Jurkat, MV4;11 and KASUMI1 cells, respectively). Comprises an ENL-binding moiety (PFI-6) joined by a linker to VHL1-Me as the ligand for von Hippel-Lindau E3 ubiquitin ligase. MS41 effectively inhibits leukemia cell proliferation and clonogenic ability in vitro and suppresses leukemia progression in a xenograft mouse model of MLL-r leukemia in vivo.PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license
Product Specifications
Molecular Weight
1031.28
Formula
C56H70N8O9S
Storage
Store at -20°C
Purity
≥97%
Chemical Name
5-[4-(Dimethylcarbamoyl)-3-hydroxyphenyl]-N-[(1R)-6-[[10-[[(2S)-1-[(2S,4R)-4-hydroxy-2-[[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]carbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-10-oxodecyl]carbamoyl]-2,3-dihydro-1H-inden-1-yl]-1,2-oxazole-3-carboxamide
CAS Number
2768610-97-3
PubChem ID
172407974
InChI Key
XPICNVKPGAOVBF-VCNVHFLLSA-N
SMILES
O=C(N[C@H]1C2=CC(C(NCCCCCCCCCC(N[C@H](C(N3[C@H](C(N[C@@H](C)C4=CC=C(C=C4)C5=C(C)N=CS5)=O)C[C@@H](O)C3)=O)C(C)(C)C)=O)=O)=CC=C2CC1)C6=NOC(C7=CC(O)=C(C(N(C)C)=O)C=C7)=C6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 103.13 | 100 |
Preparing Stock Solutions
for MS 41
The following data is based on the product molecular weight 1031.28
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.97 mL | 4.85 mL | 9.70 mL |
| 5 mM | 0.19 mL | 0.97 mL | 1.94 mL |
| 10 mM | 0.10 mL | 0.48 mL | 0.97 mL |
| 50 mM | 0.02 mL | 0.10 mL | 0.19 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Xue A potent and selective ENL degrader suppresses oncogenic gene expression and leukemia progression. Sci.Adv.
Product Specific Notices for MS 41
For research use only
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