MS 154N
Tocris Bioscience, part of Bio-Techne | Catalog # 7396
Negative control for MS 154 (Cat No. 7395)
Key Product Details
Description
Negative control for MS 154 (Cat No. 7395)
Product Description
MS 154N is a negative control for MS 154 (Cat No. 7395). The compound exhibits high binding-affinity for WT and L858R-mutant EGFR (Kd values are 3 and 4.3 nM, respectively), but does not significantly induce degradation of EGFR mutants.Licensing Information
Sold under license from Icahn School of Medicine at Mount Sinai.Product Specifications
Molecular Weight
915.46
Formula
C47H56ClFN8O8
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
3-(4-(3-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)-N-(8-((2-(1-methyl-2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)octyl)propanamide
CAS Number
2675490-97-6
PubChem ID
155515813
InChI Key
XFUDPXQGWCYCCR-UHFFFAOYSA-N
SMILES
COC1=CC2=C(C(NC3=CC(Cl)=C(C=C3)F)=NC=N2)C=C1OCCCN4CCN(CC4)CCC(NCCCCCCCCOC5=C6C(N(C(C6=CC=C5)=O)C7CCC(N(C)C7=O)=O)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 91.55 | 100 |
Preparing Stock Solutions
for MS 154N
The following data is based on the product molecular weight 915.46
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.09 mL | 5.46 mL | 10.92 mL |
| 5 mM | 0.22 mL | 1.09 mL | 2.18 mL |
| 10 mM | 0.11 mL | 0.55 mL | 1.09 mL |
| 50 mM | 0.02 mL | 0.11 mL | 0.22 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Cheng Discovery of potent and selective epidermal growth factor receptor (EGFR) bifunctional small-molecule degraders. J.Med.Chem. 2020 PMID: 31895569
Product Specific Notices for MS 154N
For research use only
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