MRS 2693 trisodium salt

Name: MRS 2693 trisodium salt
Brand: Tocris Bioscience
SKU: 2502
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2502

(1)

Citations (2)

COA / SDS

Selective P2Y6 agonist

Key Product Details

Description:	Selective P2Y₆ agonist
Alternative Names:	5-Iodo-UDP trisodium salt
Chemical Name:	5-Iodouridine-5'-O-diphosphate trisodium salt
Purity:	≥95% (HPLC)
Molecular Weight:	596

View Full Technical Details for MRS 2693 trisodium salt

Technical Data
Citations / Reviews (1)

Biological Activity for MRS 2693 trisodium salt

MRS 2693 trisodium salt is a selective P2Y₆ agonist (EC₅₀ = 0.015 μM at the hP2Y₆ receptor). Displays no activity at other P2Y subtypes. Exerts a cytoprotective effect in an in vivo mouse model of hindlimb skeletal muscle ischemia/reperfusion injury.

Technical Data for MRS 2693 trisodium salt

M. Wt	596
Formula	C₉H₁₀IN₂Na₃O₁₂P₂
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	1448858-83-0
PubChem ID	90488768
InChi Key	QWGVSYFNEAILDQ-FCIXCQMASA-K
Smiles	[Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])([O-])=O)N1C=C(I)C(=O)NC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MRS 2693 trisodium salt

Solubility

Soluble in water (supplied pre-dissolved at a concentration of 10mM)

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References for MRS 2693 trisodium salt

References are publications that support the biological activity of the product.

Mamedova Attenuation of apoptosis in vitro and ischemia/reperfusion injury in vivo in mouse skeletal muscle by P2Y₆ receptor activation. Pharmacol.Res. 2008 PMID: 18805489
Jacobson Development of selective agonists and antagonists of P2Y receptors. Purinerg.Sig.
Besada Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y₆ receptor. J.Med.Chem. 2006 PMID: 16942026