MRS 2500 tetraammonium salt
Tocris Bioscience, part of Bio-Techne | Catalog # 2159
Highly potent and selective P2Y1 antagonist
Key Product Details
Description
Highly potent and selective P2Y1 antagonist
Product Description
MRS 2500 tetraammonium salt is a highly potent and selective antagonist of the platelet P2Y1 receptor (Ki = 0.78 nM). Inhibits ADP-induced aggregation of human platelets with an IC50 value of 0.95 nM. Inhibits the upregulation of NTPDase1 by ATPγS. Prevents thrombus formation in vivo.Licensing Information
Sold under license from the NIH, US Patent 10/169975Product Specifications
Molecular Weight
629.29
Formula
C13H18N5O8P2I.4NH3
Storage
Store at -20°C
Purity
≥96% (HPLC)
Chemical Name
(1R*,2S*)-4-[2-Iodo-6-(methylamino)-9H-purin-9-yl]-2-(phosphonooxy)bicyclo[3.1.0]hexane-1-methanol dihydrogen phosphate ester tetraammonium salt
CAS Number
630103-23-0
PubChem ID
90488745
InChI Key
FVTFHHDVLNQSME-AVAGOIHISA-N
SMILES
IC4=NC1=C(C(NC)=N4)N=CN1[C@H]2C[C@H](OP(O)(O)=O)[C@@]3(COP(O)(O)=O)[C@@H]2C3.N.N.N.N
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 12.59 | 20 |
Preparing Stock Solutions
for MRS 2500 tetraammonium salt
The following data is based on the product molecular weight 629.29
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 7.95 mL | 39.73 mL | 79.45 mL |
| 1 mM | 1.59 mL | 7.95 mL | 15.89 mL |
| 2 mM | 0.79 mL | 3.97 mL | 7.95 mL |
| 10 mM | 0.16 mL | 0.79 mL | 1.59 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Lu Stimulation of the P2Y1 receptor up-regulates nucleoside-triphosphate diphosphohydrolase-1 in human retinal pigment epithelial cells. J.Pharmacol.Exp.Ther. 2007 PMID: 17626796
- Cattaneo Antiaggregatory activity in human platelets of potent antagonists of the P2Y1 receptor. Biochem.Pharmacol. 2004 PMID: 15476670
- Hechler MRS2500 [2-iodo-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3', 5'-bisphosphate], a potent, selective, and stable antagonist of the platelet P2Y1 receptor with strong antithrombotic activity in mice. J.Pharmacol.Exp.Ther. 2006 PMID: 16236815
- Kim 2-Substitution of adenine nucleotide analogues containing a bicyclo[3.1.0]hexane ring system locked in a northern conformation: enhanced potency as P2Y1 receptor antagonists. J.Med.Chem 2003 PMID: 14584948
Product Specific Notices for MRS 2500 tetraammonium salt
For research use only
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