MRS 2365

Name: MRS 2365
Brand: Tocris Bioscience
SKU: 2157

Tocris Bioscience, part of Bio-Techne | Catalog # 2157

Citations (87)

COA / SDS

Highly potent and selective P2Y1 agonist

100% Guarantee

Product Description
Licensing Information
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Highly potent and selective P2Y1 agonist

View all P2Y Receptor Agonists »

Product Description

MRS 2365 is a highly potent, selective P2Y₁ receptor agonist (EC₅₀ = 0.4 nM). Displays no activity at P2Y₁₂ receptors and only very low agonist activity at P2Y₁₃ receptors (at concentrations up to 1 μM). Increases the upregulation of NTPDase1 by ATPγS.

Licensing Information

Sold under license from the NIH, US Patent 10/169975

Product Specifications

Molecular Weight

549.28

Formula

C₁₃H₁₆N₅O₉P₂SNa₃

Storage

Store at -80°C

Purity

≥98% (HPLC)

Chemical Name

[[(1R,2R,3S,4R,5S)-4-[6-Amino-2-(methylthio)-9H-purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hex-1-yl]methyl] diphosphoric acid mono ester trisodium salt

PubChem ID

73755043

InChI Key

ZYPJOXVKTCEBCA-PVMCGCOJSA-K

SMILES

[Na+].[Na+].[Na+].CSC1=NC(N)=C2N=CN(C3[C@H]4C[C@@]4(COP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]3O)C2=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble in water (supplied pre-dissolved at a concentration of 10mM)

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

Background References

References are publications that support the biological activity of the product.

Chhatriwala Induction of novel agonist selectivity for the ADP-activated P2Y₁ receptor versus the ADP-activated P2Y₁₂ and P2Y₁₃ receptors by conformational constraint of an ADP analog. J.Pharmacol.Exp.Ther. 2004 PMID: 15345752
Lu Stimulation of the P2Y₁ receptor up-regulates nucleoside-triphosphate diphosphohydrolase-1 in human retinal pigment epithelial cells. J.Pharmacol.Exp.Ther. 2007 PMID: 17626796
Ravi Adenine nucleotide analogues locked in a northern methanocarba conformation: enhanced stability and potency as P2Y₁ receptor agonists. J.Med.Chem. 2002 PMID: 11985476