Mpro 61
Tocris Bioscience, part of Bio-Techne | Catalog # 7695
Potent non-covalent inhibitor of SARS-CoV-2 main protease
Key Product Details
Description
Potent non-covalent inhibitor of SARS-CoV-2 main protease
Product Description
Mpro 61 is a potent non-covalent inhibitor of SARS-CoV-2 main protease (IC50 = 44 nM, EC50 = 0.175 μM in the replicon assay and EC50 = 0.08 μM in the infectious SARS-CoV-2 assay); it is cell permable and exhibits no apparent cytotoxicity.Licensing Information
Sold under license from Yale University. U.S. patent application number 63/135,062.Product Specifications
Molecular Weight
565.38
Formula
C28H19Cl2FN4O4
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
5-[5-[3-Chloro-5-[(2-chlorophenyl)methoxy]-4-fluorophenyl]-6-oxo[1(6H),3'-bipyridin]-3-yl]-1-methyl-2,4(1H,3H)-pyrimidinedione
CAS Number
2679814-93-6
PubChem ID
156587560
InChI Key
KIJKUSPNZALBLD-UHFFFAOYSA-N
SMILES
CN1C=C(C2=CN(C3=CN=CC=C3)C(C(C4=CC(OCC5=C(C=CC=C5)Cl)=C(C(Cl)=C4)F)=C2)=O)C(NC1=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 11.31 | 20 |
Preparing Stock Solutions
for Mpro 61
The following data is based on the product molecular weight 565.38
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 8.84 mL | 44.22 mL | 88.44 mL |
| 1 mM | 1.77 mL | 8.84 mL | 17.69 mL |
| 2 mM | 0.88 mL | 4.42 mL | 8.84 mL |
| 10 mM | 0.18 mL | 0.88 mL | 1.77 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Zhang Optimization of triarylpyridinone inhibitors of the main protease of SARS-CoV-2 to low-nanomolar antiviral potency. ACS Med.Chem.Lett. 2021 PMID: 34408808
Product Specific Notices for Mpro 61
For research use only
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