Mpro 13b-K
Tocris Bioscience, part of Bio-Techne | Catalog # 7228
Coronavirus Mpro inhibitor
Key Product Details
Description
Coronavirus Mpro inhibitor
Product Description
Mpro 13b-K is a coronavirus Mpro inhibitor (IC50 values are 0.12, 0.58 and 0.9 μM for recombinant Mpro from SARS-CoV-2, MERS-CoV and SARS-CoV, respectively). Mpro 13b-K inhibits SARS-CoV-2 infection of human Calu3 cells (IC50 = 2.4 μM). The compound also inhibits SARS-CoV-2 replication in A549-ACE2-TMPRSS2, VeroE6 and Huh7 cell cultures (EC50 values are 0.84, 1.3 and 3.4 μM). Exhibits oral and inhalative bioavailability.Please note that this product was previously known as Mpro 13b.
Licensing Information
Sold under license from the University of LübeckProduct Specifications
Molecular Weight
593.68
Formula
C31H39N5O7
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
tert-Butyl (1-((S)-1-(((S)-4-(benzylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)amino)-3-cyclopropyl-1-oxopropan-2-yl)-2-oxo-1,2-dihydropyridin-3-yl)carbamate
CAS Number
2412965-59-2
PubChem ID
146026181
InChI Key
NLVRHQFXQFSBQK-XWGVYQGASA-N
SMILES
CC(C)(OC(NC1=CC=CN(C1=O)[C@H](C(N[C@H](C(C(NCC2=CC=CC=C2)=O)=O)C[C@@H]3CCNC3=O)=O)CC4CC4)=O)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 59.37 | 100 |
Preparing Stock Solutions
for Mpro 13b-K
The following data is based on the product molecular weight 593.68
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.68 mL | 8.42 mL | 16.84 mL |
| 5 mM | 0.34 mL | 1.68 mL | 3.37 mL |
| 10 mM | 0.17 mL | 0.84 mL | 1.68 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.34 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Cooper Diastereomeric resolution yields highly potent inhibitor of SARS-CoV-2 main protease. J.Med.Chem. 2022 PMID: 36179320
- Zhang Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors. Science 2020 PMID: 32198291
Product Specific Notices for Mpro 13b-K
For research use only
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