MOMBA
Tocris Bioscience, part of Bio-Techne | Catalog # 7926
Selective orthostatic agonist of hFFA2-DREADDs
Key Product Details
Description
Selective orthostatic agonist of hFFA2-DREADDs
Product Description
MOMBA is a selective orthosteric agonist for human free fatty acid 2 (hFFA2) engineered receptors, designer receptors activated by designer drugs (DREADD), it shows no activity to wild-type hFFA2, hFFA3, and mouse FFA2. MOMBA inhibit forskolin-stimulated cAMP levels in cells expressing the hFFA2-DREADD receptor with improved potency and equivalent efficacy to Sorbic acid (Cat. No. 7119). In hFFA2-DREADD transgenic mice, MOMBA treatment significantly reduces gut transit and promotes concentration-dependent release of GLP-1 from colonic crypts. Orally bioavailable.Product Specifications
Molecular Weight
166.17
Formula
C9H10O3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-Methoxy-3-methylbenzoic acid
CAS Number
6880-04-2
PubChem ID
2759583
InChI Key
DNMUMZLKDOZMEY-UHFFFAOYSA-N
SMILES
O=C(O)C1=CC=C(OC)C(=C1)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 16.62 | 100 | |
| Ethanol | 16.62 | 100 |
Preparing Stock Solutions
for MOMBA
The following data is based on the product molecular weight 166.17
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.02 mL | 30.09 mL | 60.18 mL |
| 5 mM | 1.20 mL | 6.02 mL | 12.04 mL |
| 10 mM | 0.60 mL | 3.01 mL | 6.02 mL |
| 50 mM | 0.12 mL | 0.60 mL | 1.20 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Miura Chemogenetics of cell surface receptors: beyond genetic and pharmacological approaches. RSC Chem.Biol. 2022 PMID: 35359495
- Milligan Chemogenetic approaches to explore the functions of free fatty acid receptor 2. Trends Pharmacol.Sci. 2021 PMID: 33495026
- Barki Chemogenetics defines a short-chain fatty acid receptor gut-brain axis. Elife 2022 PMID: 35229717
Product Specific Notices for MOMBA
For research use only
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