MOMBA

Name: MOMBA
Brand: Tocris Bioscience
SKU: 7926

Tocris Bioscience, part of Bio-Techne | Catalog # 7926

Citations (1)

COA / SDS

Selective orthostatic agonist of hFFA2-DREADDs

Key Product Details

Description:	Selective orthostatic agonist of hFFA2-DREADDs
Chemical Name:	4-Methoxy-3-methylbenzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	166.17

View Full Technical Details for MOMBA

Technical Data
Citations

Biological Activity for MOMBA

MOMBA is a selective orthosteric agonist for human free fatty acid 2 (hFFA2) engineered receptors, designer receptors activated by designer drugs (DREADD), it shows no activity to wild-type hFFA2, hFFA3, and mouse FFA2. MOMBA inhibit forskolin-stimulated cAMP levels in cells expressing the hFFA2-DREADD receptor with improved potency and equivalent efficacy to Sorbic acid (Cat. No. 7119). In hFFA2-DREADD transgenic mice, MOMBA treatment significantly reduces gut transit and promotes concentration-dependent release of GLP-1 from colonic crypts. Orally bioavailable.

Technical Data for MOMBA

M. Wt	166.17
Formula	C₉H₁₀O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	6880-04-2
PubChem ID	2759583
InChi Key	DNMUMZLKDOZMEY-UHFFFAOYSA-N
Smiles	O=C(O)C1=CC=C(OC)C(=C1)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MOMBA

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	16.62	100
	ethanol	16.62	100

Preparing Stock Solutions for MOMBA

The following data is based on the product molecular weight 166.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	6.02 mL	30.09 mL	60.18 mL
5 mM	1.20 mL	6.02 mL	12.04 mL
10 mM	0.60 mL	3.01 mL	6.02 mL
50 mM	0.12 mL	0.60 mL	1.20 mL

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References for MOMBA

References are publications that support the biological activity of the product.

Miura Chemogenetics of cell surface receptors: beyond genetic and pharmacological approaches. RSC Chem.Biol. 2022 PMID: 35359495
Milligan Chemogenetic approaches to explore the functions of free fatty acid receptor 2. Trends Pharmacol.Sci. 2021 PMID: 33495026
Barki Chemogenetics defines a short-chain fatty acid receptor gut-brain axis. Elife 2022 PMID: 35229717