MO-I-500

Product Description

MO-I-500 is a FTO inhibitor (IC₅₀ = 8.7 μM for purified FTO in vitro), which increases N⁶-methyladenosine (m6A) levels in total cellular mRNA in HeLa cells. MO-I-500 modulates levels of specific miRNAs. In a triple-negative breast cancer cell line metabolically challenged by culture without glutamine (SUM149-MA cells), MO-I-500 inhibits cell proliferation. MO-I-500 also displays anticonvulsant activity in a 6 Hz mouse model of epilepsy at nontoxic doses.

Solubility

Preparing Stock Solutions for MO-I-500

The following data is based on the product molecular weight 317.75

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.15 mL	15.74 mL	31.47 mL
5 mM	0.63 mL	3.15 mL	6.29 mL
10 mM	0.31 mL	1.57 mL	3.15 mL
50 mM	0.06 mL	0.31 mL	0.63 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Singh Important role of FTO in the survival of rare panresistant triple-negative inflammatory breast cancer cells facing a severe metabolic challenge. PLoS One. 2016 PMID: 27390851
• Zheng Synthesis of a FTO inhibitor with anticonvulsant activity. ACS.Chem.Neurosci. 2014 PMID: 24834807