MNI 137

Tocris Bioscience, part of Bio-Techne | Catalog # 4388

COA / SDS

Selective negative allosteric modulator of group II mGlu receptors

Key Product Details

Description:	Selective negative allosteric modulator of group II mGlu receptors
Chemical Name:	4-(8-Bromo-2,3-dihydro-2-oxo-1H-1,5-benzodiazepin-4-yl)-2-pyridinecarbonitrile
Purity:	≥98% (HPLC)
Molecular Weight:	341.16

View Full Technical Details for MNI 137

Technical Data
Citations

Biological Activity for MNI 137

MNI 137 is a selective negative allosteric modulator of group II mGlu receptors (IC₅₀ values are 8.3 and 12.6 nM for human and rat mGlu₂ inhibition of glutamate-induced calcium mobilization). Displays no activity at mGlu₁, mGlu₄, mGlu₅ or mGlu₈ receptors in a calcium mobilization assay.

Compound Libraries for MNI 137

MNI 137 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for MNI 137

M. Wt	341.16
Formula	C₁₅H₉BrN₄O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	946619-21-2
PubChem ID	25210562
InChi Key	KMKZCMKOSAKVGY-UHFFFAOYSA-N
Smiles	O=C1CC(C3=CC=NC(C#N)=C3)=NC2=C(C=C(Br)C=C2)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MNI 137

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	17.06	50

Preparing Stock Solutions for MNI 137

The following data is based on the product molecular weight 341.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.86 mL	29.31 mL	58.62 mL
2.5 mM	1.17 mL	5.86 mL	11.72 mL
5 mM	0.59 mL	2.93 mL	5.86 mL
25 mM	0.12 mL	0.59 mL	1.17 mL

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Reconstitution Calculator

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References for MNI 137

References are publications that support the biological activity of the product.

Hemstapat A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors. J.Pharmacol.Exp.Ther. 2007 PMID: 17416742