MLS 1547

Name: MLS 1547
Brand: Tocris Bioscience
SKU: 6171

Tocris Bioscience, part of Bio-Techne | Catalog # 6171

Citations (1)

COA / SDS

G protein-biased D2 partial agonist

Key Product Details

Description:	G protein-biased D₂ partial agonist
Chemical Name:	5-Chloro-7-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-8-quinolinol
Purity:	≥98% (HPLC)
Molecular Weight:	354.83

View Full Technical Details for MLS 1547

Technical Data
Citations

Biological Activity for MLS 1547

MLS 1547 is a G protein-biased D₂ receptor partial agonist (K_i = 1.2 μM). Stimulates D₂ receptor G protein-mediated signaling and acts as an antagonist of dopamine-mediated β-arrestin recruitment at D₂ receptors.

Compound Libraries for MLS 1547

MLS 1547 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for MLS 1547

M. Wt	354.83
Formula	C₁₉H₁₉ClN₄O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	315698-36-3
PubChem ID	1093278
InChi Key	OPEJNANYABTIGC-UHFFFAOYSA-N
Smiles	OC1=C(C=C(C2=C1N=CC=C2)Cl)CN3CCN(C4=CC=CC=N4)CC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MLS 1547

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	35.48	100

Preparing Stock Solutions for MLS 1547

The following data is based on the product molecular weight 354.83.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.82 mL	14.09 mL	28.18 mL
5 mM	0.56 mL	2.82 mL	5.64 mL
10 mM	0.28 mL	1.41 mL	2.82 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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References for MLS 1547

References are publications that support the biological activity of the product.

Free Discovery and characterization of a G protein-biased agonist that inhibits β-arrestin recruitment to the D₂ DA receptor. Mol.Pharmacol. 2014 PMID: 24755247