MLR 1023

Name: MLR 1023
Brand: Tocris Bioscience
SKU: 4582

Tocris Bioscience, part of Bio-Techne | Catalog # 4582

Citations (10)

COA / SDS

Selective allosteric activator of Lyn kinase

Key Product Details

Description:	Selective allosteric activator of Lyn kinase
Chemical Name:	5-(3-Methylphenoxy)-2(1H)-pyrimidinone
Purity:	≥98% (HPLC)
Molecular Weight:	202.21

View Full Technical Details for MLR 1023

Technical Data
Citations

Biological Activity for MLR 1023

MLR 1023 is a selective allosteric activator of Lyn kinase (EC₅₀ = 63 nM); displays no significant activity against a range of 47 other kinases, including other Src family kinases such as Fyn, Lck and Src kinase. Reduces blood glucose levels without affecting in vivo insulin secretion. Orally bioavailable.

Compound Libraries for MLR 1023

MLR 1023 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for MLR 1023

M. Wt	202.21
Formula	C₁₁H₁₀N₂O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	41964-07-2
PubChem ID	39065
InChi Key	HJQILFPVRNHTIG-UHFFFAOYSA-N
Smiles	CC1=CC(OC2=CNC(N=C2)=O)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MLR 1023

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	20.22	100
	ethanol	4.04	20

Preparing Stock Solutions for MLR 1023

The following data is based on the product molecular weight 202.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.95 mL	24.73 mL	49.45 mL
5 mM	0.99 mL	4.95 mL	9.89 mL
10 mM	0.49 mL	2.47 mL	4.95 mL
50 mM	0.10 mL	0.49 mL	0.99 mL

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Reconstitution Calculator

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References for MLR 1023

References are publications that support the biological activity of the product.

Saporito MLR-1023 is a potent and selective allosteric activator of Lyn kinase in vitro that improves glucose tolerance in vivo. J.Pharmacol.Exp.Ther. 2012 PMID: 22473614
Ochman The Lyn kinase activator MLR-1023 is a novel Ins receptor potentiator that elicits a rapid-onset and durable improvement in glucose homeostasis in animal models of type 2 diabetes. J.Pharmacol.Exp.Ther. 2012 PMID: 22431203