MLN 4760
Tocris Bioscience, part of Bio-Techne | Catalog # 3345
Potent and selective angiotensin-converting enzyme 2 (ACE2) inhibitor
Key Product Details
Description
Potent and selective angiotensin-converting enzyme 2 (ACE2) inhibitor
Product Description
MLN 4760 is a highly potent, cell-permeable and selective inhibitor of angiotensin converting enzyme 2 (ACE2) (IC50 = 0.44 nM). MLN 4760 inhibits production of angiotensin (1-7) from angiotensin II and reduces ACE2 expression and activity in an animal model of lung inflammation. Also used in Alzheimer disease (AD) research.Product Specifications
Molecular Weight
428.31
Formula
C19H23Cl2N3O4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[(1S)-1-Carboxy-3-methylbutyl]-3-[(3,5-dichlorophenyl)methyl]-L-histidine
CAS Number
305335-31-3
PubChem ID
448281
InChI Key
NTCCRGGIJNDEAB-UHFFFAOYSA-N
SMILES
ClC1=CC(CN2C(C[C@H](N[C@@H](CC(C)C)C(O)=O)C(O)=O)=CN=C2)=CC(Cl)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.83 | 100 |
Preparing Stock Solutions
for MLN 4760
The following data is based on the product molecular weight 428.31
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.33 mL | 11.67 mL | 23.35 mL |
| 5 mM | 0.47 mL | 2.33 mL | 4.67 mL |
| 10 mM | 0.23 mL | 1.17 mL | 2.33 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.47 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Sodhi A dynamic variation of pulmonary ACE2 is required to modulate neutrophilic inflammation in response to Pseudomonas aeruginosa lung infection in mice. J.Immunol. 2019 PMID: 31645418
- Mores Development of potent and selective phosphinic peptide inhibitors of angiotensin-converting enzyme 2. J.Med.Chem. 2008 PMID: 18324760
Product Specific Notices for MLN 4760
For research use only
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