MLN 4760

Name: MLN 4760
Brand: Tocris Bioscience
SKU: 3345

Tocris Bioscience, part of Bio-Techne | Catalog # 3345

Citations (2)

COA / SDS

Potent and selective angiotensin-converting enzyme 2 (ACE2) inhibitor

Key Product Details

Description:	Potent and selective angiotensin-converting enzyme 2 (ACE2) inhibitor
Chemical Name:	N-[(1S)-1-Carboxy-3-methylbutyl]-3-[(3,5-dichlorophenyl)methyl]-L-histidine
Purity:	≥98% (HPLC)
Molecular Weight:	428.31

View Full Technical Details for MLN 4760

Technical Data
Citations

Biological Activity for MLN 4760

MLN 4760 is a highly potent, cell-permeable and selective inhibitor of angiotensin converting enzyme 2 (ACE2) (IC₅₀= 0.44 nM). MLN 4760 inhibits production of angiotensin (1-7) from angiotensin II and reduces ACE2 expression and activity in an animal model of lung inflammation.

Technical Data for MLN 4760

M. Wt	428.31
Formula	C₁₉H₂₃Cl₂N₃O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	305335-31-3
PubChem ID	448281
InChi Key	NTCCRGGIJNDEAB-UHFFFAOYSA-N
Smiles	ClC1=CC(CN2C(C[C@H](N[C@@H](CC(C)C)C(O)=O)C(O)=O)=CN=C2)=CC(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MLN 4760

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	42.83	100

Preparing Stock Solutions for MLN 4760

The following data is based on the product molecular weight 428.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.33 mL	11.67 mL	23.35 mL
5 mM	0.47 mL	2.33 mL	4.67 mL
10 mM	0.23 mL	1.17 mL	2.33 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

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References for MLN 4760

References are publications that support the biological activity of the product.

Sodhi A dynamic variation of pulmonary ACE2 is required to modulate neutrophilic inflammation in response to Pseudomonas aeruginosa lung infection in mice. J.Immunol. 2019 PMID: 31645418
Mores Development of potent and selective phosphinic peptide inhibitors of angiotensin-converting enzyme 2. J.Med.Chem. 2008 PMID: 18324760