MLCK inhibitor peptide 18

Name: MLCK inhibitor peptide 18
Brand: Tocris Bioscience
SKU: 1885

Tocris Bioscience, part of Bio-Techne | Catalog # 1885

Citations (3)

COA / SDS

Selective inhibitor of myosin light chain kinase

Key Product Details

Description:	Selective inhibitor of myosin light chain kinase
Alternative Names:	Myosin Light Chain Kinase Inhibitor Peptide 18
Purity:	≥95% (HPLC)
Molecular Weight:	1324.64

View Full Technical Details for MLCK inhibitor peptide 18

Technical Data
Citations

Biological Activity for MLCK inhibitor peptide 18

MLCK inhibitor peptide 18 is a selective competitive inhibitor of myosin light chain kinase (IC₅₀ = 50 nM). Displays 4000-fold selectivity over CaM kinase II and does not inhibit PKA. Cell permeable.

Technical Data for MLCK inhibitor peptide 18

M. Wt	1324.64
Formula	C₆₀H₁₀₅N₂₃O₁₁
Single Letter Sequence	RKKYKYRRK (Modifications: Lys-9 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	224579-74-2
PubChem ID	10102940
InChi Key	JPOKAKNGULMYHZ-UILVTTEASA-N
Smiles	[H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MLCK inhibitor peptide 18

Solubility

Soluble to 1mg/ml in water

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References for MLCK inhibitor peptide 18

References are publications that support the biological activity of the product.

Zolotarevsky A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease. Gastroenterology 2002 PMID: 12105845
Lukas Identification of novel classes of protein kinase inhibitors using combinatorial peptide chemistry based on functional genomics knowledge. J.Med.Chem. 1999 PMID: 10072688