ML 7 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 4310

Selective inhibitor of myosin light chain kinase
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Key Product Details

Description

Selective inhibitor of myosin light chain kinase

View all Myosin Light Chain Kinase Inhibitors »

Product Description

ML 7 hydrochloride is a selective MLCK inhibitor (Ki = 0.3 μM). Exhibits more potent inhibition than ML 9 hydrochloride (Cat. No. 0431) Displays reversible, ATP-competitive inhibition of Ca2+-calmodulin-dependent and -independent smooth muscle MLCKs. Inhibits proplatelet formation and stabilization.

Product Specifications

Molecular Weight

452.74

Formula

C15H17IN2O2S.HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

Hexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-1H-1,4-diazepine hydrochloride

CAS Number

110448-33-4

PubChem ID

9803932

InChI Key

KDDALCDYHZIZMH-UHFFFAOYSA-N

SMILES

IC1=C(C=CC=C2S(N3CCCNCC3)(=O)=O)C2=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.64 50

Preparing Stock Solutions for ML 7 hydrochloride

The following data is based on the product molecular weight 452.74

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.42 mL 22.09 mL 44.18 mL
2.5 mM 0.88 mL 4.42 mL 8.84 mL
5 mM 0.44 mL 2.21 mL 4.42 mL
25 mM 0.09 mL 0.44 mL 0.88 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for ML 7 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ML 7 hydrochloride

For research use only

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