ML 365
Tocris Bioscience, part of Bio-Techne | Catalog # 5337
Potent and selective K2P3.1 (TASK-1) channel blocker
Key Product Details
Description
Potent and selective K2P3.1 (TASK-1) channel blocker
Product Description
ML 365 is a potent and selective TASK-1 (K2P3.1/KCNK3) channel blocker (IC50 values are 4 and 390 nM at TASK-1 and TASK-3, respectively). Displays little or no inhibition at Kir2.1, voltage-gated potassium channels, KCNQ2 and KV11.1 (hERG).Product Specifications
Molecular Weight
360.41
Formula
C22H20N2O3
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2-Methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]benzamide
CAS Number
947914-18-3
PubChem ID
46785920
InChI Key
UTAJHKSGYJSZBR-UHFFFAOYSA-N
SMILES
CC1=CC=CC(C(NC2=CC(NC(C3=CC=CC=C3OC)=O)=CC=C2)=O)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.04 | 100 | |
| Ethanol | 18.02 | 50 |
Preparing Stock Solutions
for ML 365
The following data is based on the product molecular weight 360.41
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.77 mL | 13.87 mL | 27.75 mL |
| 5 mM | 0.55 mL | 2.77 mL | 5.55 mL |
| 10 mM | 0.28 mL | 1.39 mL | 2.77 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.55 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Zou ML365: Development of bis-amides as selective inhibitors of the KCNK3/TASK1 two pore potassium channel. Probe Reports from the NIH Molecular Libraries Program 2013 PMID: 24479195
- Flaherty Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold. Bioorg.Med.Chem.Lett. 2014 PMID: 25017033
Product Specific Notices for ML 365
For research use only
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