ML 354
Tocris Bioscience, part of Bio-Techne | Catalog # 5387
Selective PAR4 antagonist
Discontinued Product
5387 has been discontinued.
View all Protease-Activated Receptor Antagonists products.
Key Product Details
Description
Selective PAR4 antagonist
Product Description
ML 354 is a selective PAR4 antagonist (IC50 = 140 nM). Exhibits 70-fold selectivity for PAR4 over PAR1.Product Specifications
Molecular Weight
282.29
Formula
C16H14N2O3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
1-Methyl-5-nitro-3-phenyl-1H-indole-2-methanol
CAS Number
89159-60-4
PubChem ID
752812
InChI Key
GNJUKVGDCUKDLF-UHFFFAOYSA-N
SMILES
CN2C1=CC=C([N+]([O-])=O)C=C1C(C3=CC=CC=C3)=C2CO
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.23 | 100 |
Preparing Stock Solutions
for ML 354
The following data is based on the product molecular weight 282.29
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.54 mL | 17.71 mL | 35.42 mL |
| 5 mM | 0.71 mL | 3.54 mL | 7.08 mL |
| 10 mM | 0.35 mL | 1.77 mL | 3.54 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.71 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wen Substituted indoles as selective protease activated receptor 4 (PAR4) antagonists: Discovery and SAR of ML354. Bioorg.Med.Chem.Lett. 2014 PMID: 25176330
Product Specific Notices for ML 354
For research use only
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