ML 349
Tocris Bioscience, part of Bio-Techne | Catalog # 5344
Selective and reversible lysophospholipase 2 (LYPLA2) inhibitor
Discontinued Product
5344 has been discontinued.
View all Hydrolase Inhibitors products.
Key Product Details
Description
Selective and reversible lysophospholipase 2 (LYPLA2) inhibitor
Product Description
ML 349 is a selective and reversible lysophospholipase 2 (LYPLA2) inhibitor (IC50 = 144 nM). Displays selectively over LYPLA1 and 20 other serine hydrolases (IC50 values are >3000 and >10,000 nM respectively).Product Specifications
Molecular Weight
454.56
Formula
C23H22N2O4S2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(5,5-Dioxido-4H-thieno[3,2-c][1]benzothiopyran-2-yl)[4-(4-methoxyphenyl)-1-piperazinyl]methanone
CAS Number
890819-86-0
PubChem ID
16193817
InChI Key
YVIJPELUPZUEJX-UHFFFAOYSA-N
SMILES
COC1=CC=C(N2CCN(C(C3=CC4=C(C(C=CC=C5)=C5S(C4)(=O)=O)S3)=O)CC2)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.09 | 20 |
Preparing Stock Solutions
for ML 349
The following data is based on the product molecular weight 454.56
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 11.00 mL | 55.00 mL | 110.00 mL |
| 1 mM | 2.20 mL | 11.00 mL | 22.00 mL |
| 2 mM | 1.10 mL | 5.50 mL | 11.00 mL |
| 10 mM | 0.22 mL | 1.10 mL | 2.20 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hernandez APT2 inhibition restores Scribble localization and S-palmitoylation in Snail-transformed cells. Cell Che.Bio. 2017 PMID: 28065656
- Adibekian Characterization of a selective, reversible inhibitor of lysophospholipase 2 (LYPLA2). Probe Reports from the NIH Molecular Libraries Program 2010 PMID: 24624468
Product Specific Notices for ML 349
For research use only
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