ML 348

Name: ML 348
Brand: Tocris Bioscience
SKU: 5345

Tocris Bioscience, part of Bio-Techne | Catalog # 5345

Citations (12)

COA / SDS

Selective and reversible lysophospholipase 1 (LYPLA1) inhibitor

Discontinued Product

5345 has been discontinued. View all Hydrolase Inhibitors products.

Key Product Details

Description:	Selective and reversible lysophospholipase 1 (LYPLA1) inhibitor
Chemical Name:	N-[2-Chloro-5-(trifluoromethyl)phenyl]-4-(2-furanylcarbonyl)-1-piperazineacetamide
Purity:	≥99% (HPLC)
Molecular Weight:	415.79

View Full Technical Details for ML 348

Technical Data
Citations

Biological Activity for ML 348

ML 348 is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC₅₀ = 210 nM). Exhibits 14-fold selectivity for LYPLA1 over LYPLA2. Also selective over a panel of ~30 other serine hydrolases.

Compound Libraries for ML 348

ML 348 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ML 348

M. Wt	415.79
Formula	C₁₈H₁₇ClF₃N₃O₃
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	899713-86-1
PubChem ID	3238952
InChi Key	OXKNHBBDOIMFFQ-UHFFFAOYSA-N
Smiles	ClC1=C(NC(CN2CCN(C(C3=CC=CO3)=O)CC2)=O)C=C(C(F)(F)F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for ML 348

References are publications that support the biological activity of the product.

Hernandez APT2 inhibition restores Scribble localization and S-palmitoylation in Snail-transformed cells. Cell Chem.Bio. 2017 PMID: 28065656
Adibekian Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 2 (LYPLA2). Probe Reports from the NIH Molecular Libraries Program 2013 PMID: 24624465