ML 339
Tocris Bioscience, part of Bio-Techne | Catalog # 5943
Potent and selective hCXCR6 antagonist
Key Product Details
Description
Potent and selective hCXCR6 antagonist
Product Description
ML 339 is a potent and selective hCXCR6 antagonist (IC50 = 140 nM); 100-fold less active at the murine CXCR6 receptor (IC50 = 18 μM). Exhibits selectivity over CXCR5, CXCR4, CCR6 and APJ receptors (IC50 >79 μM).Product Specifications
Molecular Weight
502.00
Formula
C26H32ClN3O5
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[(1R,3S,5S)-9-(2-((2-Chlorophenyl)amino)-2-exoethyl)-9-azabicyclo[3.3.1]nonan-3-yl)-3,4,5-trimethoxybenzamide
CAS Number
2579689-83-9
PubChem ID
60202254
InChI Key
SSPYAPRDKNCABY-UHFFFAOYSA-N
SMILES
O=C(NC1=C(Cl)C=CC=C1)CN2[C@H]3CCC[C@@H]2C[C@](NC(C4=CC(OC)=C(OC)C(OC)=C4)=O)([H])C3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50.2 | 100 | |
| Ethanol | 10.04 | 20 |
Preparing Stock Solutions
for ML 339
The following data is based on the product molecular weight 502.00
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.99 mL | 9.96 mL | 19.92 mL |
| 5 mM | 0.40 mL | 1.99 mL | 3.98 mL |
| 10 mM | 0.20 mL | 1.00 mL | 1.99 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.40 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hershberger Probing the CXCR6/CXCL16 Axis: targeting prevention of prostate cancer metastasis. Probe Reports from the NIH Molecular Libraries Program 2012 PMID: 24049849
Product Specific Notices for ML 339
For research use only
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