ML 337
Tocris Bioscience, part of Bio-Techne | Catalog # 4982
Selective negative allosteric modulator of mGlu3 receptors
Key Product Details
Description
Selective negative allosteric modulator of mGlu3 receptors
Product Description
ML 337 is a selective negative allosteric modulator of mGlu3 (IC50 = 593 nM). Displays no activity at mGlu1, mGlu2 or mGlu4-8 at concentrations up to 30 μM. Brain penetrant.Product Specifications
Molecular Weight
353.39
Formula
C21H20FNO3
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
[2-Fluoro-4-[2-(4-methoxyphenyl)ethynyl]phenyl][(3R)-3-hydroxy-1-piperidinyl]methanone
CAS Number
1443118-44-2
PubChem ID
60204017
InChI Key
QBCRLDPMQHPGIM-QGZVFWFLSA-N
SMILES
O=C(N1CCC[C@@H](O)C1)C(C(F)=C2)=CC=C2C#CC3=CC=C(OC)C=C3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.34 | 100 | |
| Ethanol | 7.07 | 20 |
Preparing Stock Solutions
for ML 337
The following data is based on the product molecular weight 353.39
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.83 mL | 14.15 mL | 28.30 mL |
| 5 mM | 0.57 mL | 2.83 mL | 5.66 mL |
| 10 mM | 0.28 mL | 1.41 mL | 2.83 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.57 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
Product Specific Notices for ML 337
For research use only
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