ML 334
Tocris Bioscience, part of Bio-Techne | Catalog # 5625
Inhibitor of Keap1- Nrf2 interaction
Key Product Details
Description
Inhibitor of Keap1- Nrf2 interaction
Alternative Names
LH601A
Product Description
ML 334 is an Nrf2 activator; inhibits Nrf2/Keap1 interaction (Kd = 1 μM). Promotes Nrf2 nuclear translocation and induces antioxidant response element (ARE) activity in vitro. Cell permeable.Product Specifications
Molecular Weight
446.50
Formula
C26H26N2O5
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(1S,2R)-2-[[(1S)-1-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-3,4-dihydro-2(1H)-isoquinolinyl]carbonyl]cyclohexanecarboxylic acid
CAS Number
1432500-66-7
PubChem ID
56840728
InChI Key
LNENLABLFGGAFF-BHIFYINESA-N
SMILES
O=C([C@@H]1CCCC[C@@H]1C(O)=O)N2CCC3=CC=CC=C3[C@H]2CN4C(C(C=CC=C5)=C5C4=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.65 | 100 |
Preparing Stock Solutions
for ML 334
The following data is based on the product molecular weight 446.50
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.24 mL | 11.20 mL | 22.40 mL |
| 5 mM | 0.45 mL | 2.24 mL | 4.48 mL |
| 10 mM | 0.22 mL | 1.12 mL | 2.24 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.45 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Rosini Oxidative stress in Alzheimer's disease: are we connecting the dots? J.Med.Chem. 2014 PMID: 24131448
- Hu Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction. Bioorg.Med.Chem.Lett. 2013 PMID: 23562243
Product Specific Notices for ML 334
For research use only
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