ML 315 hydrochloride

Name: ML 315 hydrochloride
Brand: Tocris Bioscience
SKU: 5700

Tocris Bioscience, part of Bio-Techne | Catalog # 5700

Citations (2)

COA / SDS

Inhibitor of Clk and DYRK kinases

Key Product Details

Description:	Inhibitor of Clk and DYRK kinases
Chemical Name:	5-(1,3-Benzodioxol-5-yl)-N-[(3,5-dichlorophenyl)methyl]-4-pyrimidinamine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	410.68

View Full Technical Details for ML 315 hydrochloride

Technical Data
Citations

Biological Activity for ML 315 hydrochloride

ML 315 hydrochloride is a inhibitor of cdc2-like kinases (Clk) and DYRK kinases (IC₅₀ values are 68, 68 and 231 nM for Clk1, Clk4 and Clk2, respectively, and 282 and 1156 nM for Dyrk1A and Dyrk1B). Shows 20-fold selectivity for Clk4 over Dyrk1A. Stable in both mouse and human plasma. Moderately cell permeable.

Compound Libraries for ML 315 hydrochloride

ML 315 hydrochloride is also offered as part of the Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for ML 315 hydrochloride

M. Wt	410.68
Formula	C₁₈H₁₃Cl₂N₃O₂.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1440251-53-5
PubChem ID	127021037
InChi Key	MNCDEAAKKQCKSX-UHFFFAOYSA-N
Smiles	ClC1=CC(CNC2=NC=NC=C2C3=CC=C(OCO4)C4=C3)=CC(Cl)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ML 315 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	37.42	100
	ethanol	18.71	50

Preparing Stock Solutions for ML 315 hydrochloride

The following data is based on the product molecular weight 410.68.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.43 mL	12.17 mL	24.35 mL
5 mM	0.49 mL	2.43 mL	4.87 mL
10 mM	0.24 mL	1.22 mL	2.43 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

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References for ML 315 hydrochloride

References are publications that support the biological activity of the product.

Coombs Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315. Bioorg.Med.Chem.Lett. 2013 PMID: 23642479