ML 289

Name: ML 289
Brand: Tocris Bioscience
SKU: 4976

Tocris Bioscience, part of Bio-Techne | Catalog # 4976

COA / SDS

Selective negative allosteric modulator of mGlu3 receptors

Discontinued Product

4976 has been discontinued. View all Group II mGluR Modulators products.

Key Product Details

Description:	Selective negative allosteric modulator of mGlu₃ receptors
Chemical Name:	[(3R)-3-(Hydroxymethyl)-1-pipridinyl][4-[2-(4-methoxyphenyl)ethynyl]phenyl]methanone
Purity:	≥98% (HPLC)
Molecular Weight:	349.42

View Full Technical Details for ML 289

Technical Data
Citations

Biological Activity for ML 289

ML 289 is a selective negative allosteric modulator at mGlu₃ receptors (IC₅₀ = 660 nM). Exhibits 15-fold selectivity for mGlu₃ over mGlu₂. Centrally penetrant.

Technical Data for ML 289

M. Wt	349.42
Formula	C₂₂H₂₃NO₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1382481-79-9
PubChem ID	56587994
InChi Key	VSLWUPHHCFQTDB-LJQANCHMSA-N
Smiles	O=C(N3CCC[C@@H](CO)C3)C(C=C2)=CC=C2C#CC1=CC=C(OC)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for ML 289

References are publications that support the biological activity of the product.

Sheffler Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM. Bioorg.Med.Chem.Lett. 2012 PMID: 22607673

ML 289

Tocris Bioscience, part of Bio-Techne | Catalog # 4976

Key Product Details

Biological Activity for ML 289

Technical Data for ML 289

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for ML 289

Product Documents for ML 289

COA

Certificate of Analysis

SDS

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