ML 277
Tocris Bioscience, part of Bio-Techne | Catalog # 4777
Selective KV7.1 (KCNQ1) potassium channel activator; augments IKs current
Key Product Details
Description
Selective KV7.1 (KCNQ1) potassium channel activator; augments IKs current
Product Description
ML 277 is a selective Kv7.1 (KCNQ1) potassium channel activator (EC50 = 260 nM). Exhibits >100-fold selectivity versus KCNQ2, KCNQ4 and hERG potassium channels. Augments IKs current of cultured human cardiomyocytes and shortens action potential duration.Product Specifications
Molecular Weight
471.59
Formula
C23H25N3O4S2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(2R)-N-[4-(4-Methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl)sulfonyl]-2-piperidinecarboxamide
CAS Number
1401242-74-7
PubChem ID
53347902
InChI Key
OXQNLLVUVDAEHC-OAQYLSRUSA-N
SMILES
O=[C@@]([C@H]3CCCCN3S(C4=CC=C(C)C=C4)(=O)=O)NC1=NC(C2=CC=C(OC)C=C2)=CS1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.16 | 100 |
Preparing Stock Solutions
for ML 277
The following data is based on the product molecular weight 471.59
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.12 mL | 10.60 mL | 21.20 mL |
| 5 mM | 0.42 mL | 2.12 mL | 4.24 mL |
| 10 mM | 0.21 mL | 1.06 mL | 2.12 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Yu Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels. Proc.Natl.Acad.Sci.U.S.A. 2013 PMID: 23650380
- Mattmann Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective Kv7.1 (KCNQ1) potassium channel activator. Bioorg.Med.Chem.Lett. 2012 PMID: 22910039
Product Specific Notices for ML 277
For research use only
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