ML 277

Name: ML 277
Brand: Tocris Bioscience
SKU: 4777
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4777

(1)

Citations (6)

COA / SDS

Selective KV7.1 (KCNQ1) potassium channel activator; augments IKs current

Key Product Details

Description:	Selective K_V7.1 (KCNQ1) potassium channel activator; augments I_Ks current
Chemical Name:	(2R)-N-[4-(4-Methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl)sulfonyl]-2-piperidinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	471.59

View Full Technical Details for ML 277

Technical Data
Citations / Reviews (1)

Biological Activity for ML 277

ML 277 is a selective K_v7.1 (KCNQ1) potassium channel activator (EC₅₀ = 260 nM). Exhibits >100-fold selectivity versus KCNQ2, KCNQ4 and hERG potassium channels. Augments I_Ks current of cultured human cardiomyocytes and shortens action potential duration.

Compound Libraries for ML 277

ML 277 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ML 277

M. Wt	471.59
Formula	C₂₃H₂₅N₃O₄S₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1401242-74-7
PubChem ID	53347902
InChi Key	OXQNLLVUVDAEHC-OAQYLSRUSA-N
Smiles	O=[C@@]([C@H]3CCCCN3S(C4=CC=C(C)C=C4)(=O)=O)NC1=NC(C2=CC=C(OC)C=C2)=CS1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ML 277

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	47.16	100

Preparing Stock Solutions for ML 277

The following data is based on the product molecular weight 471.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.12 mL	10.60 mL	21.20 mL
5 mM	0.42 mL	2.12 mL	4.24 mL
10 mM	0.21 mL	1.06 mL	2.12 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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References for ML 277

References are publications that support the biological activity of the product.

Yu Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels. Proc.Natl.Acad.Sci.U.S.A. 2013 PMID: 23650380
Mattmann Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K_v7.1 (KCNQ1) potassium channel activator. Bioorg.Med.Chem.Lett. 2012 PMID: 22910039