ML 221
Tocris Bioscience, part of Bio-Techne | Catalog # 4748
Apelin antagonist
Product Description
ML 221 is an apelin receptor (APJ) antagonist (IC50 values are 0.70 and 1.75 μM in a cAMP assay and β-arrestin assay, respectively). Displays >37-fold selectivity over the closely related angiotensin II type 1 (AT1) receptor. Exhibits no toxicity towards human hepatocytes at concentrations >50 μM.Product Specifications
Molecular Weight
385.35
Formula
C17H11N3O6S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one
CAS Number
877636-42-5
PubChem ID
7217941
InChI Key
UASIRTUMPRQVFY-UHFFFAOYSA-N
SMILES
O=C(C3=CC=C([N+]([O-])=O)C=C3)OC1=COC(CSC2=NC=CC=N2)=CC1=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.85 | 10 |
Preparing Stock Solutions
for ML 221
The following data is based on the product molecular weight 385.35
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.95 mL | 129.75 mL | 259.50 mL |
| 0.5 mM | 5.19 mL | 25.95 mL | 51.90 mL |
| 1 mM | 2.60 mL | 12.98 mL | 25.95 mL |
| 5 mM | 0.52 mL | 2.60 mL | 5.19 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Maloney Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor. Bioorg.Med.Chem.Lett. 2012 PMID: 23010269
Product Specific Notices for ML 221
For research use only
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