ML 204
Tocris Bioscience, part of Bio-Techne | Catalog # 4732
Selective TRPC4 inhibitor
Product Description
ML 204 is a blocker of TRPC4 channels (IC50 values are 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively). Exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5; displays no significant activity at TRPV1, TRPV3, TRPA1 and TRPM8 channels at concentrations up to 22 μM.Product Specifications
Molecular Weight
226.32
Formula
C15H18N2
Storage
Store at +4°C
Purity
≥99% (HPLC)
Chemical Name
4-Methyl-2-(1-piperidinyl)quinoline
CAS Number
5465-86-1
PubChem ID
230710
InChI Key
USYRQXDHKXGTCK-UHFFFAOYSA-N
SMILES
CC2=CC(N3CCCCC3)=NC1=CC=CC=C12
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 5.66 | 25 with gentle warming | |
| DMSO | 22.63 | 100 |
Preparing Stock Solutions
for ML 204
The following data is based on the product molecular weight 226.32
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.42 mL | 22.09 mL | 44.19 mL |
| 5 mM | 0.88 mL | 4.42 mL | 8.84 mL |
| 10 mM | 0.44 mL | 2.21 mL | 4.42 mL |
| 50 mM | 0.09 mL | 0.44 mL | 0.88 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Miller Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/5 ion channels. J.Biol.Chem. 2011 PMID: 21795696
- Miller Novel chemical inhibitor of TRPC4 channels. Probe Reports from the Molecular Libraries Program 2011 PMID: 22049577
Product Specific Notices for ML 204
For research use only
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