ML 193
Tocris Bioscience, part of Bio-Techne | Catalog # 4860
Potent, selective GPR55 antagonist
Key Product Details
Description
Potent, selective GPR55 antagonist
Alternative Names
CID 1261822
Product Description
ML 193 is a selective GPR55 antagonist (IC50 = 221 nM). Exhibits >27-, >145- and >145-fold selectivity for GPR55 over CB1, GPR35 and CB2, respectively. Inhibits ERK signaling in vitro.Product Specifications
Molecular Weight
527.59
Formula
C28H25N5O4S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[4-[[(3,4-Dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide
CAS Number
713121-80-3
PubChem ID
1261822
InChI Key
HTSLEZOTMYUPLU-UHFFFAOYSA-N
SMILES
CC2=CC(C)=CC1=C(C(NC4=CC=C(S(=O)(NC5=C(C)C(C)=NO5)=O)C=C4)=O)C=C(C3=CC=CC=N3)N=C12
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 52.76 | 100 |
Preparing Stock Solutions
for ML 193
The following data is based on the product molecular weight 527.59
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.90 mL | 9.48 mL | 18.95 mL |
| 5 mM | 0.38 mL | 1.90 mL | 3.79 mL |
| 10 mM | 0.19 mL | 0.95 mL | 1.90 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.38 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kotsikorou Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands. Biochemistry 2013 PMID: 24274581
- Heynen-Genel Screening for selective ligands for GPR55 - antagonists. Probe Reports from the NIH Molecular Libraries Program 2010 PMID: 22091481
Product Specific Notices for ML 193
For research use only
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