ML 179
Tocris Bioscience, part of Bio-Techne | Catalog # 4957
Selective liver receptor homolog 1 (LRH1) inverse agonist
Key Product Details
Description
Selective liver receptor homolog 1 (LRH1) inverse agonist
Product Description
ML 179 is a selective liver receptor homolog 1 (LRH1, NR5A2) inverse agonist (IC50 = 320 nM and maximum efficacy of 64% repression). Exhibits >31-fold selectivity over SF1.Product Specifications
Molecular Weight
422.44
Formula
C21H25F3N4O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
3-Cyclohexyl-6-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1H-pyrimidine-2,4-dione
CAS Number
1883548-87-5
PubChem ID
45100448
InChI Key
MFABFKUNLDYKGH-UHFFFAOYSA-N
SMILES
O=C(C=C(N3CCN(C4=CC=CC(C(F)(F)F)=C4)CC3)NC2=O)N2C1CCCCC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 21.12 | 50 |
Preparing Stock Solutions
for ML 179
The following data is based on the product molecular weight 422.44
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.73 mL | 23.67 mL | 47.34 mL |
| 2.5 mM | 0.95 mL | 4.73 mL | 9.47 mL |
| 5 mM | 0.47 mL | 2.37 mL | 4.73 mL |
| 25 mM | 0.09 mL | 0.47 mL | 0.95 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Busby Discovery of inverse agonists for the liver receptor homologue-1 (LRH1; NR5A2). Probe Reports from the NIH Molecular Libraries Program 2010 PMID: 23166964
Product Specific Notices for ML 179
For research use only
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