ML 00253764 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 4854
Melanocortin MC4 receptor antagonist; brain penetrant
Key Product Details
Description
Melanocortin MC4 receptor antagonist; brain penetrant
Product Description
ML 00253764 hydrochloride is a non-peptide, melanocortin MC4 receptor antagonist (IC50 values are 320, 810 and 2120 nM for MC4, MC3 and MC5 receptors respectively). Decreases cAMP accumulation in HEK-293 cells expressing the MC4 receptor. Increases food intake and reduces loss of lean body mass in tumor bearing mice. Brain penetrant.Product Specifications
Molecular Weight
413.71
Formula
C18H18BrFN2O.HCl
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2-[2-[2-(5-Bromo-2-methoxyphenyl)ethyl]-3-fluorophenyl]-4,5-dihydro-2-1H-imidazole hydrochloride
CAS Number
1706524-94-8
PubChem ID
90488979
InChI Key
KZUMGPQDDCBFBF-UHFFFAOYSA-N
SMILES
BrC1=CC(CCC2=C(F)C=CC=C2C3=NCCN3)=C(OC)C=C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 4.14 | 10 | |
| DMSO | 41.37 | 100 |
Preparing Stock Solutions
for ML 00253764 hydrochloride
The following data is based on the product molecular weight 413.71
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.42 mL | 12.09 mL | 24.17 mL |
| 5 mM | 0.48 mL | 2.42 mL | 4.83 mL |
| 10 mM | 0.24 mL | 1.21 mL | 2.42 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Vos Identification of 2-[2-[2-(5-bromo-2- methoxyphenyl)-ethyl]-3-fluorophenyl]-4,5-dihydro-1H-imidazole (ML00253764), a small molecule melanocortin 4 receptor antagonist that effectively reduces tumor-induced weight loss in a mouse model. J.Med.Chem. 2004 PMID: 15027849
- Tucci Potent and orally active non-peptide antagonists of the human melanocortin-4 receptor based on a series of trans-2-disubstituted cyclohexylpiperazines. Bioorg.Med.Chem.Lett. 2005 PMID: 16098742
- Nicholson Peripheral administration of a melanocortin 4-receptor inverse agonist prevents loss of lean body mass in tumor-bearing mice. J.Pharmacol.Exp.Ther. 2006 PMID: 16436498
Product Specific Notices for ML 00253764 hydrochloride
For research use only
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