MK 886

Name: MK 886
Brand: Tocris Bioscience
SKU: 1311

Tocris Bioscience, part of Bio-Techne | Catalog # 1311

Citations (51)

COA / SDS

Inhibitor of 5-lipoxygenase-activating protein (FLAP)

Key Product Details

Description:	Inhibitor of 5-lipoxygenase-activating protein (FLAP)
Alternative Names:	L-663,536
Chemical Name:	1-[(4-Chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-1H-Indole-2-propanoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	472.08

View Full Technical Details for MK 886

Technical Data
Citations

Biological Activity for MK 886

MK 886 is a potent inhibitor of 5-lipoxygenase-activating protein (FLAP) (IC₅₀ = 30 nM for inhibition of [¹²⁵I]-L-691,678 photoaffinity labelling). Inhibits leukotriene biosynthesis (IC₅₀ = 3 nM in human polymorphonuclear leukocytes). Also moderately potent PPARα antagonist (IC₅₀ = 0.5-1 μM). Orally active in vivo.

Technical Data for MK 886

M. Wt	472.08
Formula	C₂₇H₃₄ClNO₂S
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	118414-82-7
PubChem ID	3651377
InChi Key	QAOAOVKBIIKRNL-UHFFFAOYSA-N
Smiles	ClC(C=C3)=CC=C3CN(C(CC(C)(C(O)=O)C)=C2SC(C)(C)C)C1=C2C=C(C(C)C)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MK 886

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	2.36	5
	DMSO	47.21	100

Preparing Stock Solutions for MK 886

The following data is based on the product molecular weight 472.08.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.12 mL	10.59 mL	21.18 mL
5 mM	0.42 mL	2.12 mL	4.24 mL
10 mM	0.21 mL	1.06 mL	2.12 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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Reconstitution Calculator

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References for MK 886

References are publications that support the biological activity of the product.

Mancini 5-Lipoxygenase-activating protein is the target of a novel hybrid of two classes of leukotriene biosynthesis inhibitors. Mol.Pharmacol. 1992 PMID: 1538707
Gillard L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor. Can.J.Physiol.Pharmacol. 1989 PMID: 2548691
Kehrer Inhibition of peroxisome-proliferator-activated receptor (PPAR)α by MK886. Biochem.J. 2001 PMID: 11389700
Dixon Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Nature 1990 PMID: 2300173