MK 212 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 0941
5-HT2C agonist
Discontinued Product
0941 has been discontinued.
View all 5-HT2C Receptor Agonists products.
Product Description
MK 212 hydrochloride is a 5-HT receptor agonist; displays selectivity for 5-HT2C over 5-HT2A (IC50 values are 0.028 and 0.42 μM for human 5-HT2C and 5-HT2A receptors expressed in HEK293 cells respectively).Product Specifications
Molecular Weight
235.12
Formula
C8H11ClN4.HCl
Storage
Store at RT
Purity
≥99% (HPLC)
Chemical Name
6-Chloro-2-(1-piperazinyl)pyrazine hydrochloride
CAS Number
61655-58-1
PubChem ID
198421
InChI Key
PFIZGLUIYAZQFU-UHFFFAOYSA-N
SMILES
ClC1=CN=CC(N2CCNCC2)=N1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 11.76 | 50 with gentle warming |
Preparing Stock Solutions
for MK 212 hydrochloride
The following data is based on the product molecular weight 235.12
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 8.51 mL | 42.53 mL | 85.06 mL |
| 2.5 mM | 1.70 mL | 8.51 mL | 17.01 mL |
| 5 mM | 0.85 mL | 4.25 mL | 8.51 mL |
| 25 mM | 0.17 mL | 0.85 mL | 1.70 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hemrick-Luecke and Fuller Involvement of 5-HT2A receptors in the elevation of rat serum corticosterone concentration by quipazine and MK-212. Eur.J.Pharmacol. 1996 PMID: 8891601
- Jensen Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-dazepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive J.Med.Chem. 2013 PMID: 23301527
- Conn and Sanders-Bush Relative efficacies of piperazines at the phosphoinositide hydrolysis-linked serotonergic (5-HT2 and 5-HT1C) receptors. J.Pharmacol.Exp.Ther. 1987 PMID: 3039120
Product Specific Notices for MK 212 hydrochloride
For research use only
Loading...
Loading...