MK 1903

Tocris Bioscience, part of Bio-Techne | Catalog # 4622

COA / SDS

Potent and selective GPR109A (HCA2) agonist

Key Product Details

Description:	Potent and selective GPR109A (HCA₂) agonist
Chemical Name:	(4aR,5aR)-4,4a,5,5a-Tetrahydro-1H-cyclopropa[4,5]cyclopenta[1,2]pyrazole-3-carboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	164.16

View Full Technical Details for MK 1903

Technical Data
Citations

Biological Activity for MK 1903

MK 1903 is a potent and selective hydroxycarboxylic acid receptor 2 (HCA₂, GPR109A) full agonist; exhibits greater potency than niacin in a whole cell HTRF-cAMP assay (EC₅₀ values are 12.9 and 51 nM respectively). Exhibits no binding at the GRP109B receptor.

Compound Libraries for MK 1903

MK 1903 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for MK 1903

M. Wt	164.16
Formula	C₈H₈N₂O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1268882-43-4
PubChem ID	49763030
InChi Key	CUTZNERBKDMLAP-QWWZWVQMSA-N
Smiles	[H][C@@]12CC3=C(NN=C3C(O)=O)[C@@]([H])1C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MK 1903

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	16.42	100
	ethanol	8.21	50

Preparing Stock Solutions for MK 1903

The following data is based on the product molecular weight 164.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	6.09 mL	30.46 mL	60.92 mL
5 mM	1.22 mL	6.09 mL	12.18 mL
10 mM	0.61 mL	3.05 mL	6.09 mL
50 mM	0.12 mL	0.61 mL	1.22 mL

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Reconstitution Calculator

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References for MK 1903

References are publications that support the biological activity of the product.

Lauring Niacin lipid efficacy is independent of both the niacin receptor GPR109A and free fatty acid suppression. Sci.Transl.Med. 2012 PMID: 22914621
Boatman (1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[α]pentalene-4-carboxylic acid (MK-1903): a potent GPR109a agonist that lowers free fatty acids in humans. J.Med.Chem. 2012 PMID: 22435740