MK 0677
Tocris Bioscience, part of Bio-Techne | Catalog # 5272
High affinity ghrelin receptor agonist
Key Product Details
Description
High affinity ghrelin receptor agonist
Alternative Names
Ibutamoren mesylate,L-163,191
Product Description
MK 0677 is a high affinity ghrelin receptor agonist (pKi = 8.14). Growth hormone (GH) secretagog; stimulates GH release from rat pituitary cells in vitro (EC50 = 1.3 nM) and enhances GH plasma levels in vivo. Also attenuates isoproterenol-induced lipolysis in rat adipocytes in vitro. Orally bioavailable.Product Specifications
Molecular Weight
624.77
Formula
C27H36N4O5S.CH3SO3H
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-Amino-N-[(1R)-2-[1,2-dihydro-1-(methylsulfonyl)spiro[3H-indole-3,4'-piperidin]-1'-yl]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]-2-methylpropanamide methanesulfonate
CAS Number
159752-10-0
PubChem ID
6450830
InChI Key
DUGMCDWNXXFHDE-VZYDHVRKSA-N
SMILES
O=S(N2C1=CC=CC=C1C3(CCN(C([C@H](NC(C(C)(N)C)=O)COCC4=CC=CC=C4)=O)CC3)C2)(C)=O.CS(O)(=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 31.24 | 50 | |
| DMSO | 62.48 | 100 |
Preparing Stock Solutions
for MK 0677
The following data is based on the product molecular weight 624.77
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.60 mL | 8.00 mL | 16.01 mL |
| 5 mM | 0.32 mL | 1.60 mL | 3.20 mL |
| 10 mM | 0.16 mL | 0.80 mL | 1.60 mL |
| 50 mM | 0.03 mL | 0.16 mL | 0.32 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Patchett Design and biological activities of L-163,191 (MK-0677): a potent, orally active GH secretagogue. Proc.Natl.Acad.Sci.U.S.A. 1995 PMID: 7624358
- Mucciolo Ghrelin and des-acyl ghrelin both inhibit isoproterenol-induced lipolysis in rat adipocytes via a non-type 1a GH secretagogue receptor. Eur.J.Pharmacol. 2004 PMID: 15363972
- Bennett GH secretagogues and GH releasing peptides act as orthosteric super-agonists but not allosteric regulators for activation of the G protein Galpha(o1) by the Ghrelin receptor. Mol.Pharmacol. 2009 PMID: 19625579
Product Specific Notices for MK 0677
For research use only
Loading...
Loading...