(-)-Xestospongin C is a reported inhibitor of IP₃-dependent Ca²⁺ release. Inhibits bradykinin-induced Ca²⁺ release in PC12 cells and attenuates PHP-induced IL-2 production in Jurkat T cells. Exhibits no effect on ryanodine receptor-mediated Ca²⁺ release in PC12 cells and shows no apparent interaction with the IP₃ binding site. Other subsequent reports show (-)-Xestospongin C to be ineffective as an antagonist of IP₃-evoked Ca²⁺ release in IP₃ recepto- expressing DT40 cells. Cell permeable.

NOTE: (-)-Xestospongin C is typically used at a final concentration ranging from 0.5 to 10 μM. It is recommended to prepare stock solutions (10x to 100x) in DMSO or ethanol.

Product Specifications

Molecular Weight

446.71

Formula

C₂₈H₅₀N₂O₂

Storage

Store at -20°C

Chemical Name

(1R,4aR,11R,12aS,13S,16aS,23R,24aS)-Eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosinodipyridine

CAS Number

88903-69-9

PubChem ID

9846431

InChI Key

PQYOPBRFUUEHRC-HCKQMYSWSA-N

SMILES

[H][C@]12[C@@H](CCCCCC[C@@H]3CCN(CCC[C@H]4CCCCCC5)[C@@]4([H])O3)CCCN1CC[C@@H]5O2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

Background References

References are publications that support the biological activity of the product.

Saleem Interactions of antagonists with subtypes of inositol 1,4,5-trisphosphate (IP₃) receptor. Br.J.Pharmacol. 2014 PMID: 24628114
Ozaki Inhibitory mechanism of xestospongin-C on contraction and ion channels in the intestinal smooth muscle. Br.J.Pharmacol. 2002 PMID: 12466229
Dadsetan Store-operated Ca²⁺ influx causes Ca²⁺ release from the intracellular Ca²⁺ channels that is required for T cell activation. J.Biol.Chem. 2008 PMID: 18316371
Gafni Xestospongins: potent membrane permeable blockers of the inositol 1,4,5-trisphosphate receptor. Neuron 1997 PMID: 9331361

(-)-Xestospongin C

Tocris Bioscience, part of Bio-Techne | Catalog # 1280

Key Product Details

Description

Alternative Names

View all Calcium Signaling Agents »

Product Description