(-)-U-50488 hydrochloride

Name: (-)-U-50488 hydrochloride
Brand: Tocris Bioscience
SKU: 0496
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0496

(2)

Citations (21)

COA / SDS

Selective κ agonist; more active enantiomer of (±)-U-50488 (Cat. No. 0495)

Key Product Details

Description:	Selective κ agonist; more active enantiomer of (±)-U-50488 (Cat. No. 0495)
Chemical Name:	trans-(-)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	405.79

View Full Technical Details for (-)-U-50488 hydrochloride

Technical Data
Citations / Reviews (2)

Biological Activity for (-)-U-50488 hydrochloride

(-)-U-50488 hydrochloride is a more active enantiomer of (±)-U-50488.

Racemate and (+)-enantiomer also available.

Technical Data for (-)-U-50488 hydrochloride

M. Wt	405.79
Formula	C₁₉H₂₆Cl₂N₂O.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	114528-79-9
PubChem ID	9931141
InChi Key	KGMMGVIYOHGOKQ-APTPAJQOSA-N
Smiles	O=C(CC3=CC(Cl)=C(Cl)C=C3)N([C@@H]1[C@@H](N2CCCC2)CCCC1)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (-)-U-50488 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	8.12	20
	DMSO	40.58	100

Preparing Stock Solutions for (-)-U-50488 hydrochloride

The following data is based on the product molecular weight 405.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.46 mL	12.32 mL	24.64 mL
5 mM	0.49 mL	2.46 mL	4.93 mL
10 mM	0.25 mL	1.23 mL	2.46 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

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Reconstitution Calculator

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References for (-)-U-50488 hydrochloride

References are publications that support the biological activity of the product.

Zhu Agonist-induced desensitization and down-regulation of the human kappa opioid receptor expressed in chinese hamster ovary cells. J.Pharmacol.Exp.Ther. 1998 PMID: 9535991
Morrone Withdrawal contractures of guinea-pig isolated ileum after acute activation of κ opioid receptors. Br.J.Pharmacol. 1993 PMID: 8388301
Reddy and Bhargava Effect of chronic administration of U-50,488H, a kappa opioid receptor agonist on central DA (D₂) receptors of the rat. Eur.J.Pharmacol. 1993 PMID: 8390939
De Costa Synthesis and absolute configuration of optically pure enantiomers of a κ-opioid receptor selective antagonist. FEBS Lett. 1987 PMID: 2822490