(-)-Terreic acid
Tocris Bioscience, part of Bio-Techne | Catalog # 1405
Selective inhibitor of BTK
Discontinued Product
1405 has been discontinued.
View all Brutons Tyrosine Kinase (BTK) Inhibitors products.
Key Product Details
Description
Selective inhibitor of BTK
Product Description
(-)-Terreic acid is a selective inhibitor of Bruton's tyrosine kinase (BTK). Inhibits the interaction between PKCbII and BTK (IC50 ~ 30 mM) and the catalytic activity of BTK but does not affect the activity of PKC. Has little effect on the activities of Lyn, Syk, PKA, casein kinase I, ERK1, ERK2 and p38 kinases.Product Specifications
Molecular Weight
154.12
Formula
C7H6O4
Storage
Store at +4°C
Purity
≥99% (HPLC)
Chemical Name
(1R,6S)-3-Hydroxy-4-methyl-7-oxabicyclo[4.1.0]hept-3-ene-2,5-dione
CAS Number
121-40-4
PubChem ID
91437
InChI Key
ATFNSNUJZOYXFC-RQJHMYQMSA-N
SMILES
CC1=C(O)C(=O)[C@@H]2O[C@@H]2C1=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 3.08 | 20 |
Preparing Stock Solutions
for (-)-Terreic acid
The following data is based on the product molecular weight 154.12
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 32.44 mL | 162.21 mL | 324.42 mL |
| 1 mM | 6.49 mL | 32.44 mL | 64.88 mL |
| 2 mM | 3.24 mL | 16.22 mL | 32.44 mL |
| 10 mM | 0.65 mL | 3.24 mL | 6.49 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Subramanian In vivo and in vitro studies on the binding nature of terreic acid with macromolecules such as protein and nucleic acids. Toxicol.Lett. 1982 PMID: 7080093
- Yamamoto Studies on terreic acid. Jpn.J.Antibiot. 1980 PMID: 7190624
- Kawakami Terreic acid, a quinone epoxide inhibitor of Bruton's tyrosine kinase. Proc.Natl.Acad.Sci.U.S.A. 1999 PMID: 10051623
Product Specific Notices for (-)-Terreic acid
For research use only
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