(-)-Nicotine ditartrate
Tocris Bioscience, part of Bio-Techne | Catalog # 3546
Prototypical nAChR agonist
Key Product Details
Description
Prototypical nAChR agonist
Product Description
(-)-Nicotine ditartrate is a nicotinic acetylcholine receptor (nAChR) agonist (Ki values are 1, > 1000, 4000 and 7130 nM at α4β2, α1β1δγ, rat α7 and human α7 respectively). Exhibits vasoconstrictive, hypertensive and prothrombotic activity in vivo.Product Specifications
Molecular Weight
462.41
Formula
C10H14N2.2C4H6O6
Storage
Desiccate at RT
Purity
≥99% (HPLC)
Chemical Name
(S)-(-)-1-Methyl-2-(3-pyridyl)pyrrolidine (L-(+))-ditartrate salt
CAS Number
65-31-6
PubChem ID
11957628
InChI Key
RFEJUZJILGIRHQ-OMDKHLBYSA-N
SMILES
CN(CCC2)[C@@H]2[C@]1=CC=CN=C1.OC([C@H](O)[C@@H](O)C(O)=O)=O.OC([C@H](O)[C@@H](O)C(O)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 46.24 | 100 | |
| DMSO | 34.68 | 75 |
Preparing Stock Solutions
for (-)-Nicotine ditartrate
The following data is based on the product molecular weight 462.41
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.16 mL | 10.81 mL | 21.63 mL |
| 5 mM | 0.43 mL | 2.16 mL | 4.33 mL |
| 10 mM | 0.22 mL | 1.08 mL | 2.16 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.43 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Xiao Rat α3/β4 subtype of neuronal nicotinic acetylcholine receptor stably expressed in a transfected cell line: Pharmacology of ligand binding and function. Mol.Pharmacol. 1998 PMID: 9687574
- Mayhan Acute infusion of nicotine potentiates NE-induced vasoconstriction in the hamster cheek pouch. J.Lab.Clin.Med. 1999 PMID: 10385481
- Donnelly-Roberts ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: A novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I In vitro characterization. J.Pharmacol.Exp.Ther. 1998 PMID: 9580626
Product Specific Notices for (-)-Nicotine ditartrate
For research use only
⚠ WARNING: This product can expose you to chemicals including Nicotine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
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