(-)-[3R,4S]-Chromanol 293B
Tocris Bioscience, part of Bio-Techne | Catalog # 1475
IKs blocker. Enantiomer of Chromanol 293B (Cat. No. 1412)
Key Product Details
Description
IKs blocker. Enantiomer of Chromanol 293B (Cat. No. 1412)
Product Description
(-)-[3R,4S]-Chromanol 293B is a enantiomer that selectively inhibits the slow component of delayed rectifier K+ current (IKs). Block is use-dependent and 7-fold more potent than the (+)-(3S,4R) enantiomer (IC50 values are 1.36 and 9.6 μM respectively). Has negligible inhibitory action at KV11.1 (hERG) channels (IC50 > 30 μM).Racemate also available.
Product Specifications
Molecular Weight
324.39
Formula
C15H20N2O4S
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
N-[(3R,4S)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methylethanesulfonamide
CAS Number
163163-24-4
PubChem ID
121846
InChI Key
HVSJHHXUORMCGK-UONOGXRCSA-N
SMILES
CCS(=O)(=O)N(C)[C@@H]1[C@@H](O)C(C)(C)OC2=C1C=C(C=C2)C#N
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.44 | 100 with gentle warming | |
| Ethanol | 32.44 | 100 with gentle warming |
Preparing Stock Solutions
for (-)-[3R,4S]-Chromanol 293B
The following data is based on the product molecular weight 324.39
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.08 mL | 15.41 mL | 30.83 mL |
| 5 mM | 0.62 mL | 3.08 mL | 6.17 mL |
| 10 mM | 0.31 mL | 1.54 mL | 3.08 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Seebohm A kinetic study on the stereospecific inhibition of KCNQ1 and IKs by the chromanol 293B. Br.J.Pharmacol. 2001 PMID: 11739240
- Yang Stereoselective interactions of the enantiomers of chromanol 293B with human voltage-gated potassium channels. J.Pharmacol.Exp.Ther. 2000 PMID: 10945846
- Lerche Molecular impact of MinK on the enantiospecific block of IKs by chromanols. Br.J.Pharmacol. 2001 PMID: 11139424
Product Specific Notices for (-)-[3R,4S]-Chromanol 293B
For research use only
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