Milnacipran hydrochloride

Name: Milnacipran hydrochloride
Brand: Tocris Bioscience
SKU: 3286

Tocris Bioscience, part of Bio-Techne | Catalog # 3286

COA / SDS

5-HT and NA reuptake inhibitor (SNRI)

Discontinued Product

3286 has been discontinued. View all 5-HT Transporter Inhibitors products.

Key Product Details

Description:	5-HT and NA reuptake inhibitor (SNRI)
Chemical Name:	(1R,2S)-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	282.81

View Full Technical Details for Milnacipran hydrochloride

Technical Data
Citations

Biological Activity for Milnacipran hydrochloride

Milnacipran hydrochloride is a orally active 5-HT and noradrenalin re-uptake inhibitor (SNRI) (IC₅₀ values are 203 and 100 nM respectively) that displays no affinity at a range of other receptors. Causes adaptive changes to α₁-adrenergic and 5-HT_2A serotonergic systems when administered repeatedly. Exhibits antidepressive and antinociceptive activities in vivo.

Technical Data for Milnacipran hydrochloride

M. Wt	282.81
Formula	C₁₅H₂₂N₂O.HCl
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	101152-94-7
PubChem ID	73416954
InChi Key	GIGAIOSMEXBLQA-IBWNGBJLSA-N
Smiles	NC[C@@H]1[C@@]([C@](N(CC)CC)=O)([C@]2=CC=CC=C2)C1.NC[C@H]3[C@]([C@](N(CC)CC)=O)([C@]4=CC=CC=C4)C3.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Milnacipran hydrochloride

References are publications that support the biological activity of the product.

Maj Pharmacological effect of milnacipran, a new antidepressant, given repeatedly on the α₁-adrenergic and serotonergic 5-HT_2A systems. J.Neural.Transm. 2000 PMID: 11145008
Suzuki Antiallodynic and antihyperalgesic effect of milnac. in mice with spinal nerve ligation. Anesth.Analg. 2008 PMID: 18349211
Moret Biochemical profile of midalcipran (F 2207), 1-phenyl-1-diethyl-aminocarbonyl-2-aminomethyl-cyclopropane (z) hydrochloride, a potential fourth generation antidepressant drug. Neuropharmacology 1985 PMID: 3005901

Milnacipran hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 3286

Key Product Details

Biological Activity for Milnacipran hydrochloride

Technical Data for Milnacipran hydrochloride

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Milnacipran hydrochloride

Product Documents for Milnacipran hydrochloride

COA

Certificate of Analysis

SDS

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