Mibefradil dihydrochloride

Name: Mibefradil dihydrochloride
Brand: Tocris Bioscience
SKU: 2198
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2198

(1)

Citations (37)

COA / SDS

CaV3.x blocker

Key Product Details

Description:	Ca_V3.x blocker
Alternative Names:	Ro 40-5967
Chemical Name:	(1S,2S)-2-[2-[[3-(1H-Benzimidazol-2yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl methoxyacetoacetate dihydrochloride
Purity:	≥97% (HPLC)
Molecular Weight:	568.56

View Full Technical Details for Mibefradil dihydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for Mibefradil dihydrochloride

Mibefradil dihydrochloride is a Ca²⁺ channel blocker with moderate selectivity for T-type Ca²⁺ channels displaying IC₅₀ values of 2.7 μM and 18.6 μM for T-type and L-type channels respectively. Antihypertensive agent.

Compound Libraries for Mibefradil dihydrochloride

Mibefradil dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Mibefradil dihydrochloride

M. Wt	568.56
Formula	C₂₉H₃₈FN₃O₃.2HCl
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	116666-63-8
PubChem ID	60662
InChi Key	MTJLQTFHJIHXIX-GDUXWEAWSA-N
Smiles	Cl.Cl.COCC(=O)O[C@]1(CCN(C)CCCC2=NC3=C(N2)C=CC=C3)CCC2=C(C=CC(F)=C2)[C@@H]1C(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Mibefradil dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	28.43	50
	DMSO	56.86	100

Preparing Stock Solutions for Mibefradil dihydrochloride

The following data is based on the product molecular weight 568.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.76 mL	8.79 mL	17.59 mL
5 mM	0.35 mL	1.76 mL	3.52 mL
10 mM	0.18 mL	0.88 mL	1.76 mL
50 mM	0.04 mL	0.18 mL	0.35 mL

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Reconstitution Calculator

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References for Mibefradil dihydrochloride

References are publications that support the biological activity of the product.

Veniant Hemodynamic profile of Ro 40-5967 in conscious rats: comparison with diltiazem, verapamil, and amlod. J.Cardiovasc.Pharmacol. 1991 PMID: 1725005
Mehrke The Ca(++)-channel blocker Ro 40-5967 blocks differently T-type and L-type Ca++ channels. J.Pharmacol.Exp.Ther. 1994 PMID: 7996461
Osterrieder and Holck In vitro pharmacologic profile of Ro 40-5967, a novel Ca²⁺ channel blocker with potent vasodilator but weak inotropic action. J.Cardiovasc.Pharmacol. 1989 PMID: 2472524