MI 2 (MALT1 inhibitor)
Tocris Bioscience, part of Bio-Techne | Catalog # 4848
MALT1 inhibitor
Product Description
MI 2 (MALT1 inhibitor) is a MALT1 inhibitor (IC50 = 5.84 μM). Binds directly to MALT1 and irreversibly suppresses protease function. Decreases NF-κB activity induced by MALT1. Inhibits cell proliferation and MALT1-mediated cleavage activity. Suppresses human TMD8 and HBL-1 activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) tumor xenografts in mice and primary human ABC-DLBCLs ex vivo.Product Specifications
Molecular Weight
455.72
Formula
C19H17Cl3N4O3
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2-Chloro-N-[4-[5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl]phenylacetamide
CAS Number
1047953-91-2
PubChem ID
45942672
InChI Key
TWJGQZBSEMDPQP-UHFFFAOYSA-N
SMILES
O=C(CCl)NC(C=C3)=CC=C3N1C(C2=CC(Cl)=C(Cl)C=C2)=NC(OCCOC)=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.57 | 100 | |
| Ethanol | 9.11 | 20 |
Preparing Stock Solutions
for MI 2 (MALT1 inhibitor)
The following data is based on the product molecular weight 455.72
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.19 mL | 10.97 mL | 21.94 mL |
| 5 mM | 0.44 mL | 2.19 mL | 4.39 mL |
| 10 mM | 0.22 mL | 1.10 mL | 2.19 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Fontan MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo. Cancer Cell 2012 PMID: 23238016
Product Specific Notices for MI 2 (MALT1 inhibitor)
For research use only
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