Metyrapone

Tocris Bioscience, part of Bio-Techne | Catalog # 3292

11-β hydroxylase inhibitor
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Key Product Details

Description

11-β hydroxylase inhibitor

View all Hydroxylase Inhibitors »

Product Description

Metyrapone is a cytochrome P450 inhibitor. Blocks glucocorticoid synthesis via inhibition of steroid 11-β hydroxylase (CYP11B1) activity (IC50 = 7.83 μM). Also inhibits CYP3A4 and cytochrome P450-mediated ω/ω-1 hydroxylase activity.

Product Specifications

Molecular Weight

226.27

Formula

C14H14N2O

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-Methyl-1,2-di-3-pyridinyl-1-propanone

CAS Number

54-36-4

PubChem ID

4174

InChI Key

FJLBFSROUSIWMA-UHFFFAOYSA-N

SMILES

O=C(C2=CN=CC=C2)C(C)(C)C1=CC=CN=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 2.26 10
DMSO 22.63 100

Preparing Stock Solutions for Metyrapone

The following data is based on the product molecular weight 226.27

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.42 mL 22.10 mL 44.19 mL
5 mM 0.88 mL 4.42 mL 8.84 mL
10 mM 0.44 mL 2.21 mL 4.42 mL
50 mM 0.09 mL 0.44 mL 0.88 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for Metyrapone

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Metyrapone

For research use only

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