Methylmalonate

Name: Methylmalonate
Brand: Tocris Bioscience
SKU: 4979

Tocris Bioscience, part of Bio-Techne | Catalog # 4979

COA / SDS

Succinate dehydrogenase inhibitor

Key Product Details

Description:	Succinate dehydrogenase inhibitor
Chemical Name:	2-Methylpropanedioic acid
Purity:	≥98%
Molecular Weight:	118.09

View Full Technical Details for Methylmalonate

Technical Data
Citations

Biological Activity for Methylmalonate

Methylmalonate is an intracellularly produced malonate, a reversible succinate dehydrogenase inhibitor used to generate Huntington's disease models. Induces apoptotic cell death in striatal neurons.

Technical Data for Methylmalonate

M. Wt	118.09
Formula	C₄H₆O₄
Storage	Store at RT
Purity	≥98%
CAS Number	516-05-2
PubChem ID	487
InChi Key	ZIYVHBGGAOATLY-UHFFFAOYSA-N
Smiles	OC(C(C)C(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Methylmalonate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1.1eq. NaOH	11.81	100
	DMSO	11.81	100

Preparing Stock Solutions for Methylmalonate

The following data is based on the product molecular weight 118.09.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	8.47 mL	42.34 mL	84.68 mL
5 mM	1.69 mL	8.47 mL	16.94 mL
10 mM	0.85 mL	4.23 mL	8.47 mL
50 mM	0.17 mL	0.85 mL	1.69 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

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Reconstitution Calculator

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References for Methylmalonate

References are publications that support the biological activity of the product.

McLaughlin Methylmalonate toxicity in primary neuronal cultures. Neuroscience 1998 PMID: 9692761
Ehrlich Huntington's disease and the striatal medium spiny neuron: cell-autonomous and non-cell-autonomous mechanisms of disease. Neurotherapeutics 2012 PMID: 22441874
Beal and Ferrante Experimental therapeutics in transgenic mouse models of Huntington's disease. Nat.Rev.Neurosci. 2004 PMID: 15100720