Mesulergine hydrochloride

Name: Mesulergine hydrochloride
Brand: Tocris Bioscience
SKU: 1644

Tocris Bioscience, part of Bio-Techne | Catalog # 1644

Citations (7)

COA / SDS

5-HT2A and 5-HT2C antagonist; also D2-like partial agonist

Key Product Details

Description:	5-HT_2A and 5-HT_2C antagonist; also D₂-like partial agonist
Alternative Names:	CU-32-085
Chemical Name:	N'-[(8-α1,6-dimethylergolin-8-yl]-N,N-dimethylsulfamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	398.95

View Full Technical Details for Mesulergine hydrochloride

Technical Data
Citations

Biological Activity for Mesulergine hydrochloride

Mesulergine hydrochloride is a 5-HT_2A and _2C receptor antagonist (pA₂ values are 9.1 for each receptor) and D₂-like dopamine receptor partial agonist (K_i = 8 nM). Displays antiprolactin and antiparkinsonian effects in vivo.

Technical Data for Mesulergine hydrochloride

M. Wt	398.95
Formula	C₁₈H₂₆N₄O₂S.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	72786-12-0
PubChem ID	155746
InChi Key	HANSYUJEPWNHIM-IVMONYBCSA-N
Smiles	CN2C1=CC=CC([C@]4([H])[C@@](N(C)C[C@@H](NS(=O)(N(C)C)=O)C4)([H])C3)=C1C3=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Mesulergine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	39.9	100
	water	1.99	5 with gentle warming

Preparing Stock Solutions for Mesulergine hydrochloride

The following data is based on the product molecular weight 398.95.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.51 mL	12.53 mL	25.07 mL
5 mM	0.50 mL	2.51 mL	5.01 mL
10 mM	0.25 mL	1.25 mL	2.51 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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References for Mesulergine hydrochloride

References are publications that support the biological activity of the product.

Marko DA agonistic potency of two novel prolactin release-inhibiting ergolines. Eur.J.Pharmacol. 1984 PMID: 6468500
Markstei Mesulergine and its 1,20-N,N-bidemethylated metabolite interact directly with D₁- and D₂-receptors. Eur.J.Pharmacol. 1983 PMID: 6230246
Hoyer VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 1994 PMID: 7938165