Melatonin

Name: Melatonin
Brand: Tocris Bioscience
SKU: 3550
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3550

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Citations (60)

COA / SDS

Endogenous hormone; agonist at MT1 and MT2

Key Product Details

Description:	Endogenous hormone; agonist at MT₁ and MT₂
Chemical Name:	N-Acetyl-5-methoxytryptamine
Purity:	≥98% (HPLC)
Molecular Weight:	232.28

View Full Technical Details for Melatonin

Technical Data
Citations / Reviews (1)

Biological Activity for Melatonin

Melatonin is an endogenous hormone that acts as an agonist at melatonin receptors MT₁ and MT₂. Exhibits a prominent role in the control of circadian rhythm, displays immunomodulatory activity and acts as a powerful antioxidant in vivo.

Compound Libraries for Melatonin

Melatonin is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Melatonin

M. Wt	232.28
Formula	C₁₃H₁₆N₂O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	73-31-4
PubChem ID	896
InChi Key	DRLFMBDRBRZALE-UHFFFAOYSA-N
Smiles	O=C(C)NCCC2=CNC1=CC=C(OC)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Melatonin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	11.61	50

Preparing Stock Solutions for Melatonin

The following data is based on the product molecular weight 232.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	8.61 mL	43.05 mL	86.10 mL
2.5 mM	1.72 mL	8.61 mL	17.22 mL
5 mM	0.86 mL	4.31 mL	8.61 mL
25 mM	0.17 mL	0.86 mL	1.72 mL

Molarity Calculator

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Dilution Calculator

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Reconstitution Calculator

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References for Melatonin

References are publications that support the biological activity of the product.

Fischer Melatonin as a major skin protectant: from free radical scavenging to DNA damage repair. Exp.Dermatol. 2008 PMID: 18643846
Cardinali Melatonin and melatonergic drugs on sleep: possible mechanisms of action. Int.J.Neurosci. 2009 PMID: 19326288
Bubenik Thirty four years since the discovery of gastrointestinal melatonin. J.Physiol.Pharmacol. 2008 PMID: 18812627