Mecamylamine hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2843
Non-competitive nAChR antagonist
Key Product Details
Description
Non-competitive nAChR antagonist
Product Description
Mecamylamine hydrochloride is a non-competitive nicotinic acetylcholine receptor antagonist. Displays antidepressant-like effects in mice.Product Specifications
Molecular Weight
203.75
Formula
C11H21N.HCl
Storage
Desiccate at RT
Chemical Name
(1R,2S,4S)-rel-N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride
CAS Number
110691-49-1
PubChem ID
13221
InChI Key
LRJARFKQBBVCIV-FDYABGJLSA-N
SMILES
C[C@]1(NC)C(C)(C)[C@@H]2CC[C@H]1C2.Cl.C[C@@]1(NC)C(C)(C)[C@H]2CC[C@@H]1C2.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 20.37 | 100 | |
| DMSO | 20.37 | 100 |
Preparing Stock Solutions
for Mecamylamine hydrochloride
The following data is based on the product molecular weight 203.75
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.91 mL | 24.54 mL | 49.08 mL |
| 5 mM | 0.98 mL | 4.91 mL | 9.82 mL |
| 10 mM | 0.49 mL | 2.45 mL | 4.91 mL |
| 50 mM | 0.10 mL | 0.49 mL | 0.98 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Rabenstein The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not β2- or α7-nicotinic acetylcholine receptor subunit knockout mice. Psychopharmacol.
- Ostroumov Modeling study of mecamylamine block of muscle type acetylcholine receptors. Eur.Biophys.J. 2007 PMID: 17938901
Product Specific Notices for Mecamylamine hydrochloride
For research use only
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